Substituted esters of cyclic alcohols



Patented Dec. 15,1953

SUBSTITUTED ESTERS OF CYCLIC ALCOHOLS Frederick Leonard, Jackson Heights, N. Y., as-

signor to Warner-Hudnut, Inc., New York, N. Y., a corporationof Delaware N Drawing. Application July 21, 1951, Serial No. 238,029

11 Claims. (Cl. 260293.4)

This invention relates to new compounds of pharmaceutical interest, particularly as antispasmodics.

In accordance with my invention there are produced compounds having the structural formula:

S CCOOX wherein R denotes a cyclohexenyl or cyclopentenyl radical; R denotes hydrogen, a short chain alkyl radical or halogen, which members may be the same or different; and X denotes a basic-nitrogen containing radical selected from the group consisting of dialkylamino-substituted cyclohexyl radicals; dialkylamino substituted mononuclear aryl hydrocarbon radicals; piperidyl and N-alkyl substituted piperidyl radicals; and 3-pyridy1radicals. These compounds have been found to possess effective antispasmodic activity.

The compounds of my invention may be readily prepared by reacting an acyl halide of the formula CC CH2} 8 1 in which R and R are as above defined and Hal denotes halogen with a compound of formula X-OH, in which X is as above defined, such as the following: dialkylaminocyclohexanols such as 2-diethylaminocyclohexanol, 3 dimethylaminocyclohexanol, 4-diethy1aminocyclohexanol, 4-dimethylamino-S, 5-dimethylcyclohexanol, 3-dimethylamino-6 isopropyl 2 methylcyclohexanol, 3-(N-methyl N ethyl) aminocyclohexanol; piperidol and alkylpiperidols such as 1-methyl-2-piperidol, l-ethyl-B-piperidol, 1- methyl-l-piperidol, 1,2,6-trimethyl-4 piperidol, 1,2-dimethyl-4-isopropyl-3 piperidol; dialkylaminophenols such as Z-diethylaminophen01, 3-dimethylaminophenol, 4-diethylaminophenol, 3,5-dimethyl-4-dimethy1aminophenol, 3- dimethylamino-6-isopropyl-2 methylphenol, 4- (N-ethyl-N-methyhaminophenol; and 3-pyridols such as 3-pyridol, 6-methyl-3-pyridol, 2,6- dimethyl-3-pyridol, 2,4,G-trimethyl-S-pyridol, 2- iodo-3-pyridol. This reaction may be conveniently carried out in a suitable solvent such as ben- 2 zene, under reflux. The thienylacetyl chlorides from which the compounds of my invention are prepared may be readily obtained by treatment of the corresponding alpha-substituted thienylacetic acids with excess thionyl chloride in a suitable solvent such as benzene, under reflux.

The free basic esters of my invention are waterinsoluble liquids. Water-soluble salts may be formed by treatment of the free bases with acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, tartaric acid, citric acid or succinic acid or with suitable organic halides e. g., alkyl halides such as methyl chloride or methyl bromide, aralkyl halides such as benzyl chloride or benzyl bromide or other organic halides such as thienylmethyl chloride.

The following examples are illustrative of my invention:

EXAMPLE I To a solution of 627 gms. (3.02 moles) of alpha- (A -cyclopentenyl)-2-thienylacetic acid in 1510 cc. of dry benzene, 395 gms. (3.32 moles) of thionyl chloride were added slowly, the mixture heated to boiling, and refluxed for one hour. The solvent and excess thionyl chloride were removed under vacuum and the residue distilled at 3 mm. The fraction boiling at 1l4-140 C. was collected and refractionated at 2.7 mm. to give 317 gms. of pure alpha-(M-cyclopentenyl)-2 thienylacetyl chloride, B. P. 121l25 C., n 1.555. Analysis gave the following results.

Calculated for C11H11ClOS: 0:58.29, H=4.89, Cl=15.65. Found: C=58.45, H=4.70, 01:15.60.

5.75 grams of l-methyl-l piperidol in 50 cc. of benzene was added slowly to a solution of 1.14 grams of alpha-(A -cyclopentenyl) -2-thienylacetyl chloride prepared as above described in cc. of benzene, and the'mixture refluxed for 4 hours. 40 cc. of water was added, followed by 10 cc. of concentrated hydrochloric acid. The resulting organic and aqueous layers were separated and the benzene solution extracted with 25 cc. of Water. The combined aqueous solutions were made basic with 16 gms. of sodium hydroxide in 24 cc. of water, and the liberated base was separated from the alkali layer; the aqueous layer was extracted twice with 30 cc. portions of ether and the ether extracts combined with the base and dried over anhydrous potassium carbonate. The dried solution was then evaporated to remove the ether and the residue was distilled at one micron pressure, the fraction boiling at 130-134 C. being recovered. This fraction was dissolved in an ether-ethyl acetate mixture the stoichiometrlc quantity of 2M citric acid in absolute ethanol was added. The salt crystallized, was filtered ofl, washed with ethyl acetate, and then with ether. The dried product weighed 7.16 gms., M. P. 142-143 C. Recrystallization from isopropyl alcohol gave 6.24 grams of analytically pure lmethyl-};plperidyl aIphm-(M-cyclopentenyl)-2-thienylacetate citrate; M. P. 141.5 142.5 C. Anaylsis gave the following results:

Calculated for CasHzuNOoS: C=E 5.l, I l=6.2 Found: :55.14, H=6.26.

EXAMPLE II 5.78 grams of 2-diethylaminocyclohexanol in 50 ml. of dry benzene was added dropwise to rapidly stirred solution of 8.15 g ns. of alpha- (AL cyclopentenyl)-2-thienylacetyl chloride in 100 ml. of dry benzene. The mixture was refluxed for 11 hours, after which time it was cooled and 50 ml. of water added. The mixture was made bas c by the addition f 1. emee sodium 1 3-. erexide in i mlof ater- We resu tin weenie and anueeus la ers were seuareted. and the equ one phase e tracted tw ce with m}. nert eus 9f ethe T e ether extracts and he P eemie p e re eemb ned. c ncentrat d n same. and the residue distilled t 99.05 mm" iv n 5. mef our: base, B.- 1?- 12mm n1) 14 5 1 1. 5 mate ial was dissolved i 3. .Qf absolute ethyl cetate an treated w th the steieh qmetne amount of .51 ethe elie I-he sal was c yst lli ed b epneentre ine the so u io in iew. hover ng th resi ue wit Q SQlF P ether, and chillin for se eral da s The y eld of rude h dmbremide was 5-5 sms- M- R lfi-firleiie crude product was depolarized b reflux n an ethyl acetate olu ion tbereet with 0-6 em of Norit A, filtering oil the carbon, and adding Skellysolve B to the agpearance of turbidity in order to crystallize the salt. 3.97 gms. of hydrobram l.-- 3:.5. was thus ePte w e' 6n i t, eer etel izefii a save L 1 t a s Granar -tel m e -d; mem -qu ue Phe yp meete wue yle tet 'h btjaa si M!! 1. .31 5? Q.- eae e s i il ie ssuer Ca ul ed erq ifi erme =5 -.o.0.

eyelet s ew-t le her- 9; ere Esau??? {H 4 cyclopentenyll' 2 thienylacetate, 3 dimethylamino-fi-isopropyl 2 methylcyclohexyl alpha- ,(A -eyclol exenyll 2 thieny1acetate, l-methyl-2- pipericlyl alpha-jtzl cyclopentenyl) 2 thienylacetate, 1,2 diniethyl 4 isopropyl-3-piperidyl alpha- (M-cyclohexenyl) -2-thienylacetate, 2-diethyla-minophenyl alpha -(A cyclohexenyl) -2- thienylacetate, 3 dimethylaminophenyl alpha- (A? eyclohexenyl) 2 thienylacetate, 3,5 dimethyl-4-dimethylaminophenyl alpha- (A -cycloeeuenyu 2 thie yi eeea. 2.- ur yl-N- W rem nenhenyl e he-le?.-e l enten Z-thienylacetate, 5-methy1-3-pyridyl alphaflAF- eyel phenten b .2 thieu lee ete t methyl 5 when eleherie re lehexenyll :2: thienylacetate, 2-iodo-3-'pyridyl alpha-(M-cyclohexenyl)-2-thienylacetate, l-methyl-4-piperidyl alpha (e' -cyclohexenyl) 3 'r'n'ethyl-Z-thienylacetate, l-methyl 2 piperidyl alpha-(h -cyclopentenyl) -4-chloro-2-thienylacetate, as well as 'f alt 9? h s as e t s btein q 11, acco dance wi htheIfQregei'pg d s sure Since certain chap es ineybe'made in'the com 7/ poun s Itet-ie describ d w thout deper ue o the scope of my invention, it is intended that all Ru I p i Lee...

Wherein R denotes a member selected from the group consisting of cyclohexenyl and cyclopentenyl radical-SIR denotes a mem er 'sele'cteq from the roupconsisung or h'ydro'genfs'h'ort chain enema-sa een and halogens? and a ct-cue raeuear' attached to 'the oxyge'rfat iclear carbon atorn, Said yc liradica1 being selected froin the grout consisting 'o'ruioowe'r alkyl) arnjino' substitut'd cyclohexyl radicals, 'the dres er "alkyll' amino-substituted pne riyi radi calsfthe bi'peridyl and Nfshortchai'n alkyl substituted pip i'idyl' radica ls'arid S -pyridy1 radicals, nd a t x Salts of the compound l-methyl-4 -piperidyl alpha '(a -eyclobentenyl)' 2-thienylacetatei' tlif compound 'l 'rnethyl' l'i piperidyl lbha ihf-cyclolrexenyl)j-ZfihienyIacetateI" Q 4. iE alts p'r'pteeompouna 3 pyfidyl alpha-(A cyclopentenyl) Z-thienylacetate." 5'. Salts of the con'rboun'd 3-pyri dyl alpha-(A cyclo nyl)f2- thienylacetate'." .e- .euti e theeqmeq nd'zue v nexy e ate-whe lie"teny er ue u eea 5 6 7. The compound 1-methy1-4-piperidy1 alpha- References Cited in the file of this patent (A -cyc1openteny1) -2-thieny1acetate. UNITED STATES PATENTS 8. The compound 1-methy1-4-piperidy1 alpha- (M-cyclohexenyl)-2-thieny1acetate. Number N Date h h 2 1 5 2,507,449 Martm et a1. May 9, 1950 9. T e compound 3-pyr1dy1 alp a-(A -cyc 0- 2,533,002 Feldkamp 5, 1950 Pentenyl) -2'th1eny1aetate- 2,533,795 Moffett 5931.23, 1951 The m d -pyri y1 alp a-(A l 2,541,634 Bncke Feb 13, 1951 hexenyl) -2-thieny1acetate. 2,561,385 Leonard July 24, 1951 11. The compound Z-diethylaminocyclohexyl alpha-(M-cyclopentenyl)-2-thieny1acetate. 10 FOREIGN PATENTS Number Country Date FREDERICK LEONARD. 625,811 Great Britain July 5, 1949 

1. A COMPOUND SELECTED FROM THE GROUP CONSISTING OF COMPOUNDS HAVING THE GENERAL FORMULA: 